Look, if you had one shot, or one opportunity To seize everything you ever wanted - One moment.. Would you capture it or just let it slip?

'Chuck: I have a big meeting in a few hours.
Blair: A few hours is hours from now.
Chuck: Seriously. It's important. I have to keep my focus. It's with Sean McPherson. I've only got one shot at this with him ...
Blair: As opposed to me, who's just some endless vault of do-overs?'

'Serena: It doesn't make sense!

Blair: Feelings never do. They get you all confused. Then they drive you around for hours before they drop you right back where you started.'

'Blair: Ladies, you can get your tiny brains to rest. Once again the world has proven - anything you can do, I can do better.'

'Chuck: I'm sorry. I screwed up.

Blair: It's too late, Chuck. I stood by you through all of this but I can't watch you self-destruct any longer.'

'Blair: He doesn't want my help.
Serena: So that's just it? You're going to abandon him for some society matrons?
Blair: Those "matrons" as you call them, are helping me build a life. All Chuck can do is destroy one. I'm not abandoning Chuck. I'm just saving myself.'

'Jack: Chuck, your father wouldn't have wanted this.
Chuck: Dear old Dad? Unfortunately all I know is what he didn't want. Which is me. I'm Chuck Bass!!! ... No one cares.
Blair: I do. Don't you understand? I'll always be here. I don't want you going anywhere. I couldn't bear it. So whatever you want to do to yourself, please don't do it to me. Please.
Chuck: I'm sorry.'

'Blair: Whatever you're going through, I wanna be there for you.
Chuck: We've talked about this. You are not my girlfriend.
Blair: But I am me. And you are you. We're Chuck and Blair. Blair and Chuck. The worst thing you've ever done, the darkest thought you've ever had, I will stand by you through anything.
Chuck: And why would you do that.
Blair: Because I love you.
Chuck: Well, that's too bad.'

'Blair: Only a masochist could ever love such a narcissist.'

'Blair: A woman needs to be with a man who thinks of only her. Anything else is a non-starter. Tell him how you feel.'

'Serena: Plenty of women have been both lover and muse to famous artists. Like Picasso.
Blair: Serena, a guy start's out in his blue period and everything's great. But it's only a matter of time until he's all into cubism and it's some other girl's eye coming out of her forehead.'

'Chuck: I'll have one drink with you. Unless you can convince why I should stay of course.
Blair. Well, just because we've reached an impasse at a certain issue doesn't mean we can't be friends.'

giving up....